TAP Family: Rel
<a target="_blank" class="awithout" href="http://pfam.xfam.org/family/PF00554">PFAM</a> (0): The Rel homology domain (RHD) is a protein domain found in a family of eukaryotic transcription factors, which includes NF-κB, NFAT, among others. The RHD is composed of two immunoglobulin-like beta barrel subdomains that grip the DNA in the major groove. The N-terminal specificity domain resembles the core domain of the p53 transcription factor, and contains a recognition loop that interacts with DNA bases. The C-terminal dimerization domain contains the site for interaction with I-kappaB.
References:
Müller, CW; Rey, FA; Sodeoka, M; Verdine, GL; Harrison, SC. 1995. Structure of the NF-kappa B p50 homodimer bound to DNA. Nature. 373(6512):311-7
Lang, D; Weiche, B; Timmerhaus, G; Richardt, S; Riano-Pachon, DM; Correa, LG; Reski, R; Mueller-Roeber, B; Rensing, SA. 2010. Genome-wide phylogenetic comparative analysis of plant transcriptional regulation: a timeline of loss, gain, expansion, and correlation with complexity. Genome Biol Evol. 2: 488-503"
