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TAP Family: HMG

Griess et al (1993): HMG boxes were initially identified as DNA-binding domains of the human RNA polymerase I (pol I) transcription factor hUBF and the animal high-mobility-group (HMG) protein family HMG1.

This TAP family belongs to the ARID structural class of the Helix-turn-helix domains structural superclass, as defined in Plant-TFClass (Blanc-Mathieu et al. 2024)


References:

Grasser, KD; Teo, SH; Lee, KB; Broadhurst, RW; Rees, C; Hardman, CH; Thomas, JO. 1998. DNA-binding properties of the tandem HMG boxes of high-mobility-group protein 1 (HMG1). Eur. J. Biochem. 253(3):787-95

Griess, EA; Rensing, SA; Grasser, KD; Maier, UG; Feix, G. 1993. Phylogenetic relationships of HMG box DNA-binding domains. J. Mol. Evol. 37(2):204-10"

Wissmüller, S; Kosian, T; Wolf, M; Finzsch, M; Wegner, M. 2006. The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. Nucleic Acids Res. 34(6):1735-44"

Blanc-Mathieu, Romain et al. 2024. Plant-TFClass: a structural classification for plant transcription factors. Trends in Plant Science, Volume 29, Issue 1, 40 - 51

Name: HMG
Class: TR
Number of species containing the TAP: 569 (list)
Number of available proteins: 7173
Domain rules :

TAP distribution:
Minimum Maximum Average Median
1 164 12.606326889279 10

Download phylogenetic tree (Newick format):

View NJ Tree
View ML Tree

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