TAP Family: DDT
Doerks et al (2001): Homology-based sequence analyses have revealed the presence of a novel domain (DDT) in bromodomain PHD finger transcription factors (BPTFs), chromatin remodeling factors of the BAZ-family and other putative nuclear proteins. This domain is characterized by a number of conserved aromatic and charged residues and is predicted to consist of three alpha helices. Recent studies indicate a likely DNA-binding function for the DDT domain.
This TAP family belongs to the Homeo domain factors structural class of the Helix-turn-helix domains structural superclass, as defined in Plant-TFClass (Blanc-Mathieu et al. 2024)
References:
Doerks, T; Copley, R; Bork, P. 2001. DDT -- a novel domain in different transcription and chromosome remodeling factors. Trends Biochem. Sci. 26(3):145-6
Blanc-Mathieu, Romain et al. 2024. Plant-TFClass: a structural classification for plant transcription factors. Trends in Plant Science, Volume 29, Issue 1, 40 - 51
