TAP Family: C2H2
Englbrecht et al (2004): C2H2 zinc fingers (ZF) display a wide range of functions, from DNA or RNA binding to the involvement in protein-protein interactions. Therefore ZFPs not only act in transcriptional regulation, either directly or through site-specific modification and/or regulation of chromatin, but also participate in RNA metabolism and in other cellular functions that probably require specific protein contacts of the ZF domain.
This TAP family belongs to the C2H2 zinc finger factors structural class of the Zinc-coordinating DNA-binding domains structural superclass, as defined in Plant-TFClass (Blanc-Mathieu et al. 2024)
References:
Ciftci-Yilmaz, S; Mittler, R. 2008. The zinc finger network of plants. Cell. Mol. Life Sci. 65(7-8):1150-60
Englbrecht, CC; Schoof, H; Böhm. S. 2004. Conservation, diversification and expansion of C2H2 zinc finger proteins in the Arabidopsis thaliana genome. BMC Genomics. 5(1):39"
Iuchi, S. 2001. Three classes of C2H2 zinc finger proteins. Cell. Mol. Life Sci. 58(4):625-35"
Lang, D; Weiche, B; Timmerhaus, G; Richardt, S; Riano-Pachon, DM; Correa, LG; Reski, R; Mueller-Roeber, B; Rensing, SA. 2010. Genome-wide phylogenetic comparative analysis of plant transcriptional regulation: a timeline of loss, gain, expansion, and correlation with complexity. Genome Biol Evol. 2: 488-503"
Takatsuji, H. 1999. Zinc-finger proteins: the classical zinc finger emerges in contemporary plant science. Plant Mol. Biol. 39(6):1073-8"
Blanc-Mathieu, Romain et al. 2024. Plant-TFClass: a structural classification for plant transcription factors. Trends in Plant Science, Volume 29, Issue 1, 40 - 51
