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TAP Family: C2H2

Englbrecht et al (2004): C2H2 zinc fingers (ZF) display a wide range of functions, from DNA or RNA binding to the involvement in protein-protein interactions. Therefore ZFPs not only act in transcriptional regulation, either directly or through site-specific modification and/or regulation of chromatin, but also participate in RNA metabolism and in other cellular functions that probably require specific protein contacts of the ZF domain.


References:

Ciftci-Yilmaz, S; Mittler, R. 2008. The zinc finger network of plants. Cell. Mol. Life Sci. 65(7-8):1150-60

Englbrecht, CC; Schoof, H; Böhm. S. 2004. Conservation, diversification and expansion of C2H2 zinc finger proteins in the Arabidopsis thaliana genome. BMC Genomics. 5(1):39"

Iuchi, S. 2001. Three classes of C2H2 zinc finger proteins. Cell. Mol. Life Sci. 58(4):625-35"

Lang, D; Weiche, B; Timmerhaus, G; Richardt, S; Riano-Pachon, DM; Correa, LG; Reski, R; Mueller-Roeber, B; Rensing, SA. 2010. Genome-wide phylogenetic comparative analysis of plant transcriptional regulation: a timeline of loss, gain, expansion, and correlation with complexity. Genome Biol Evol. 2: 488-503"

Takatsuji, H. 1999. Zinc-finger proteins: the classical zinc finger emerges in contemporary plant science. Plant Mol. Biol. 39(6):1073-8"

Name: C2H2
Class: TF
Number of species containing the TAP: 677 (list)
Number of available proteins: 63278
Domain rules :

TAP distribution:
Minimum Maximum Average Median
1 1794 93.468242245199 78

Download phylogenetic tree (Newick format):

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