TAP Family: ADA2
SWIRM domain proteins can be subdivided into 3 subfamilies, namely SWI3-type, LSD1-type (Lysine-specific demethylase 1), and Ada2-type (Adenosine deaminase isoenzymes 2), based on their domain architectures and sequence homology (Gao et al., 2012). ADA2-type proteins are known to be involved in lysine activation and transcriptional activation (Sterner et al., 2002).
References:
Gao, Y., Yang, S., Yuan, L., Cui, Y., & Wu, K. (2012). Comparative Analysis of SWIRM Domain-Containing Proteins in Plants. Comparative and Functional Genomics, 2012, 1–8. https://doi.org/10.1155/2012/310402
Sterner, D. E., Wang, X., Bloom, M. H., Simon, G. M., & Berger, S. L. (2002). The SANT Domain of Ada2 Is Required for Normal Acetylation of Histones by the Yeast SAGA Complex. Journal of Biological Chemistry, 277(10), 8178–8186. https://doi.org/10.1074/jbc.M108601200
