TAP Subfamily: NF-YA
Bernadt et al (2005): NF-Y is a bifunctional transcription factor capable of activating or repressing transcription. NF-Y specifically recognizes CCAAT box motifs present in many eukaryotic promoters. The mechanisms involved in regulating its activity are poorly understood.
This TAP family belongs to the Heteromeric CCAAT-binding factors structural class of the Other all-alpha-helical DNA-binding domains structural superclass, as defined in Plant-TFClass (Blanc-Mathieu et al. 2024)
References:
Zanetti, ME; Rípodas, C; Niebel, A. 2017. Plant NF-Y transcription factors: Key players in plant-microbe interactions, root development and adaptation to stress. Biochim Biophys Acta. 1860(5):645-654
Lang, D; Weiche, B; Timmerhaus, G; Richardt, S; Riano-Pachon, DM; Correa, LG; Reski, R; Mueller-Roeber, B; Rensing, SA. 2010. Genome-wide phylogenetic comparative analysis of plant transcriptional regulation: a timeline of loss, gain, expansion, and correlation with complexity. Genome Biol Evol. 2: 488-503"
Bernadt, CT; Nowling, T; Wiebe, MS; Rizzino, A. 2005. NF-Y behaves as a bifunctional transcription factor that can stimulate or repress the FGF-4 promoter in an enhancer-dependent manner. Gene Expr. 12(3):193-212"
Li, XY; Mantovani, R; Hooft van Huijsduijnen, R; Andre, I; Benoist, C; Mathis, D. 1992. Evolutionary variation of the CCAAT-binding transcription factor NF-Y. Nucleic Acids Res. 20(5):1087-91"
Blanc-Mathieu, Romain et al. 2024. Plant-TFClass: a structural classification for plant transcription factors. Trends in Plant Science, Volume 29, Issue 1, 40 - 51
