TAP Subfamily: C2H2_IDD
The Cys2-His2 (C2H2) zinc-finger protein family is present in all eukaryotes and among the largest families of eukaryotic transcription factors (Seetharam & Stuart, 2013). One identified plant-specific subfamily of this large protein family is the Indeterminate Domain (IDD) subfamily of TFs, which was first reported in Zea mays (Coelho et al., 2018; Prochetto & Reinheimer, 2020). Proteins belonging to the IDD subfamily can be distinguished from the remaining C2H2 members by the fact that they contain a highly conserved N-terminal IDD domain in addition to further C2H2 zinc finger domains (Prochetto & Reinheimer, 2020). Among previously identified functions controlled by C2H2-IDD proteins are metabolic and development processes like flowering time, root development, leaf differentiation and the regulation of the C4 Kranz anatomy (Coelho et al., 2018; Prochetto & Reinheimer, 2020).
This TAP family belongs to the C2H2 zinc finger factors structural class of the Zinc-coordinating DNA-binding domains structural superclass, as defined in Plant-TFClass (Blanc-Mathieu et al. 2024)
References:
Seetharam, A., & Stuart, G. W. (2013). A study on the distribution of 37 well conserved families of C2H2 zinc finger genes in eukaryotes. BMC Genomics, 14(1), 420. https://doi.org/10.1186/1471-2164-14-420
Coelho, C. P., Huang, P., Lee, D.-Y., & Brutnell, T. P. (2018). Making Roots, Shoots, and Seeds: IDD Gene Family Diversification in Plants. Trends in Plant Science, 23(1), 66–78. https://doi.org/10.1016/j.tplants.2017.09.008
Prochetto, S., & Reinheimer, R. (2020). Step by step evolution of Indeterminate Domain (IDD) transcriptional regulators: from algae to angiosperms. Annals of Botany, 126(1), 85–101. https://doi.org/10.1093/aob/mcaa052
Blanc-Mathieu, Romain et al. 2024. Plant-TFClass: a structural classification for plant transcription factors. Trends in Plant Science, Volume 29, Issue 1, 40 - 51
